Effects of ultrasound energy on thrombi in vitro
Identifieur interne : 000A00 ( Main/Exploration ); précédent : 000999; suivant : 000A01Effects of ultrasound energy on thrombi in vitro
Auteurs : F. Philippe [France] ; G. Drobinski [France] ; C. Bucherer [France] ; A. Ankri [France] ; C. Lacombe [France] ; D. Kremer [France] ; D. Brisset [France] ; G. Montalescot [France]Source :
- Catheterization and Cardiovascular Diagnosis [ 0098-6569 ] ; 1993-02.
English descriptors
- Teeft :
- Arterial thrombi, Atherosclerotic plaques, Calibration grid, Cellular debris, Clot, Clot dissolution, Coll cardiol, Continuous mode, Disruption, Disruption time, Dissolution, Elisa method, Fibrin, Guide wire, Large particulates, Microscopic examination, Optimal frequency, Plastic tubing, Power output, Previous studies, Resonance scanning function, Streptokinase, Thrombus, Titanium probe, Ultrasonic angioplasty device, Ultrasonic clot disruption, Ultrasonic energy, Ultrasound, Ultrasound energy, Ultrasound generator, Whole blood, Whole blood clot, Whole blood clots.
Abstract
Ultrasonic energy may be used for dissolution of venous or arterial thrombi. However, its effects may depend on the mode of ultrasonic vibration and on the length of the probe. We investigated the in vitro effects of an ultrasonic angioplasty device coupled with a 130 cm‐long flexible titanium probe, with an incorporated automatic optimal frequency of resonance scanning function and continuous mode of emission. Sixteen clots were treated of which eight were whole blood and eight cell‐free. In each of these groups, four were treated in association with streptokinase and four by ultrasound alone. The ages of the clots in these subgroups of four were 1, 3, 7, and 15 days. All thrombi were dissolved in 6 min or less (3′15″ ± 1′35″) at a mean optimal frequency of resonance of 19,444 Hz. Ninety‐six percent of the debris were less than 10 μ. Fewer than 1% of the particulates were larger than 100 μ. These large particulates were observed in disrupted whole blood clots and were almost non‐existent in disrupted cell‐free clots. They were very fragile. Clot dissolution was not speeded by adding streptokinase to ultrasound. Ultrasound did not induce D‐Dimer production, and its effect was most likely to be due to cavitation. Ultrasound energy could represent an advance for thrombotic vascular occlusion therapy, provided that more flexible probes can be devised. © 1993 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ccd.1810280217
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000351
- to stream Istex, to step Curation: 000350
- to stream Istex, to step Checkpoint: 000694
- to stream Main, to step Merge: 000A10
- to stream Main, to step Curation: 000A00
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of ultrasound energy on thrombi in vitro</title><author><name sortKey="Philippe, F" sort="Philippe, F" uniqKey="Philippe F" first="F." last="Philippe">F. Philippe</name></author><author><name sortKey="Drobinski, G" sort="Drobinski, G" uniqKey="Drobinski G" first="G." last="Drobinski">G. Drobinski</name></author><author><name sortKey="Bucherer, C" sort="Bucherer, C" uniqKey="Bucherer C" first="C." last="Bucherer">C. Bucherer</name></author><author><name sortKey="Ankri, A" sort="Ankri, A" uniqKey="Ankri A" first="A." last="Ankri">A. Ankri</name></author><author><name sortKey="Lacombe, C" sort="Lacombe, C" uniqKey="Lacombe C" first="C." last="Lacombe">C. Lacombe</name></author><author><name sortKey="Kremer, D" sort="Kremer, D" uniqKey="Kremer D" first="D." last="Kremer">D. Kremer</name></author><author><name sortKey="Brisset, D" sort="Brisset, D" uniqKey="Brisset D" first="D." last="Brisset">D. Brisset</name></author><author><name sortKey="Montalescot, G" sort="Montalescot, G" uniqKey="Montalescot G" first="G." last="Montalescot">G. Montalescot</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E1D92B3F4B68C35481105CEBD5FDDB771BA8A7C0</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1002/ccd.1810280217</idno><idno type="url">https://api.istex.fr/document/E1D92B3F4B68C35481105CEBD5FDDB771BA8A7C0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000351</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000351</idno><idno type="wicri:Area/Istex/Curation">000350</idno><idno type="wicri:Area/Istex/Checkpoint">000694</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000694</idno><idno type="wicri:doubleKey">0098-6569:1993:Philippe F:effects:of:ultrasound</idno><idno type="wicri:Area/Main/Merge">000A10</idno><idno type="wicri:Area/Main/Curation">000A00</idno><idno type="wicri:Area/Main/Exploration">000A00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of ultrasound energy on thrombi in vitro</title><author><name sortKey="Philippe, F" sort="Philippe, F" uniqKey="Philippe F" first="F." last="Philippe">F. Philippe</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Drobinski, G" sort="Drobinski, G" uniqKey="Drobinski G" first="G." last="Drobinski">G. Drobinski</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Correspondence address: Service de Cardiology, C.H.U. Pitiéa‐Salpéatriégre, 75651 Paris Cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bucherer, C" sort="Bucherer, C" uniqKey="Bucherer C" first="C." last="Bucherer">C. Bucherer</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ankri, A" sort="Ankri, A" uniqKey="Ankri A" first="A." last="Ankri">A. Ankri</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lacombe, C" sort="Lacombe, C" uniqKey="Lacombe C" first="C." last="Lacombe">C. Lacombe</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kremer, D" sort="Kremer, D" uniqKey="Kremer D" first="D." last="Kremer">D. Kremer</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brisset, D" sort="Brisset, D" uniqKey="Brisset D" first="D." last="Brisset">D. Brisset</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Montalescot, G" sort="Montalescot, G" uniqKey="Montalescot G" first="G." last="Montalescot">G. Montalescot</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Cardiology, Biorheology, and Hematology, Centre Hospitaller Universitaire PitiéA‐SalpéAtriéGre, the Department of Vascular Surgery, H⊚pital Saint Joseph, and the ENSAM Engineering School, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Catheterization and Cardiovascular Diagnosis</title><title level="j" type="alt">CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS</title><idno type="ISSN">0098-6569</idno><idno type="eISSN">1097-0304</idno><imprint><biblScope unit="vol">28</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="173">173</biblScope><biblScope unit="page" to="178">178</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1993-02">1993-02</date></imprint><idno type="ISSN">0098-6569</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0098-6569</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Arterial thrombi</term><term>Atherosclerotic plaques</term><term>Calibration grid</term><term>Cellular debris</term><term>Clot</term><term>Clot dissolution</term><term>Coll cardiol</term><term>Continuous mode</term><term>Disruption</term><term>Disruption time</term><term>Dissolution</term><term>Elisa method</term><term>Fibrin</term><term>Guide wire</term><term>Large particulates</term><term>Microscopic examination</term><term>Optimal frequency</term><term>Plastic tubing</term><term>Power output</term><term>Previous studies</term><term>Resonance scanning function</term><term>Streptokinase</term><term>Thrombus</term><term>Titanium probe</term><term>Ultrasonic angioplasty device</term><term>Ultrasonic clot disruption</term><term>Ultrasonic energy</term><term>Ultrasound</term><term>Ultrasound energy</term><term>Ultrasound generator</term><term>Whole blood</term><term>Whole blood clot</term><term>Whole blood clots</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ultrasonic energy may be used for dissolution of venous or arterial thrombi. However, its effects may depend on the mode of ultrasonic vibration and on the length of the probe. We investigated the in vitro effects of an ultrasonic angioplasty device coupled with a 130 cm‐long flexible titanium probe, with an incorporated automatic optimal frequency of resonance scanning function and continuous mode of emission. Sixteen clots were treated of which eight were whole blood and eight cell‐free. In each of these groups, four were treated in association with streptokinase and four by ultrasound alone. The ages of the clots in these subgroups of four were 1, 3, 7, and 15 days. All thrombi were dissolved in 6 min or less (3′15″ ± 1′35″) at a mean optimal frequency of resonance of 19,444 Hz. Ninety‐six percent of the debris were less than 10 μ. Fewer than 1% of the particulates were larger than 100 μ. These large particulates were observed in disrupted whole blood clots and were almost non‐existent in disrupted cell‐free clots. They were very fragile. Clot dissolution was not speeded by adding streptokinase to ultrasound. Ultrasound did not induce D‐Dimer production, and its effect was most likely to be due to cavitation. Ultrasound energy could represent an advance for thrombotic vascular occlusion therapy, provided that more flexible probes can be devised. © 1993 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Philippe, F" sort="Philippe, F" uniqKey="Philippe F" first="F." last="Philippe">F. Philippe</name></region><name sortKey="Ankri, A" sort="Ankri, A" uniqKey="Ankri A" first="A." last="Ankri">A. Ankri</name><name sortKey="Brisset, D" sort="Brisset, D" uniqKey="Brisset D" first="D." last="Brisset">D. Brisset</name><name sortKey="Bucherer, C" sort="Bucherer, C" uniqKey="Bucherer C" first="C." last="Bucherer">C. Bucherer</name><name sortKey="Drobinski, G" sort="Drobinski, G" uniqKey="Drobinski G" first="G." last="Drobinski">G. Drobinski</name><name sortKey="Drobinski, G" sort="Drobinski, G" uniqKey="Drobinski G" first="G." last="Drobinski">G. Drobinski</name><name sortKey="Kremer, D" sort="Kremer, D" uniqKey="Kremer D" first="D." last="Kremer">D. Kremer</name><name sortKey="Lacombe, C" sort="Lacombe, C" uniqKey="Lacombe C" first="C." last="Lacombe">C. Lacombe</name><name sortKey="Montalescot, G" sort="Montalescot, G" uniqKey="Montalescot G" first="G." last="Montalescot">G. Montalescot</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A00 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A00 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= BernheimV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E1D92B3F4B68C35481105CEBD5FDDB771BA8A7C0
|texte= Effects of ultrasound energy on thrombi in vitro
}}
| This area was generated with Dilib version V0.6.33. |  |